TY  - JOUR
AU  - Stamenković, Miroslav
AU  - Lukić, Vesna
AU  - Šuvakov, Sonja
AU  - Simić, Tatjana
AU  - Senćanić, Ivan
AU  - Plješa-Ercegovac, Marija
AU  - Jakšić, Vesna
AU  - Babović, Siniša
AU  - Matić, Marija
AU  - Radosavljević, Aleksandra
AU  - Savić-Radojević, Ana
AU  - Đukić, Tatjana
PY  - 2018
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1157
AB  - AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.
PB  - IJO Press, Xi An
T2  - International Journal of Ophthalmology
T1  - GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers
EP  - 1520
IS  - 9
SP  - 1514
VL  - 11
DO  - 10.18240/ijo.2018.09.14
ER  - 

@article{
author = "Stamenković, Miroslav and Lukić, Vesna and Šuvakov, Sonja and Simić, Tatjana and Senćanić, Ivan and Plješa-Ercegovac, Marija and Jakšić, Vesna and Babović, Siniša and Matić, Marija and Radosavljević, Aleksandra and Savić-Radojević, Ana and Đukić, Tatjana",
year = "2018",
abstract = "AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.",
publisher = "IJO Press, Xi An",
journal = "International Journal of Ophthalmology",
title = "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers",
pages = "1520-1514",
number = "9",
volume = "11",
doi = "10.18240/ijo.2018.09.14"
}

Stamenković, M., Lukić, V., Šuvakov, S., Simić, T., Senćanić, I., Plješa-Ercegovac, M., Jakšić, V., Babović, S., Matić, M., Radosavljević, A., Savić-Radojević, A.,& Đukić, T.. (2018). GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology
IJO Press, Xi An., 11(9), 1514-1520.
https://doi.org/10.18240/ijo.2018.09.14

Stamenković M, Lukić V, Šuvakov S, Simić T, Senćanić I, Plješa-Ercegovac M, Jakšić V, Babović S, Matić M, Radosavljević A, Savić-Radojević A, Đukić T. GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology. 2018;11(9):1514-1520.
doi:10.18240/ijo.2018.09.14 .

Stamenković, Miroslav, Lukić, Vesna, Šuvakov, Sonja, Simić, Tatjana, Senćanić, Ivan, Plješa-Ercegovac, Marija, Jakšić, Vesna, Babović, Siniša, Matić, Marija, Radosavljević, Aleksandra, Savić-Radojević, Ana, Đukić, Tatjana, "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers" in International Journal of Ophthalmology, 11, no. 9 (2018):1514-1520,
https://doi.org/10.18240/ijo.2018.09.14 . .