@article{
author = "Samardžić, T. and Marinković, Dragan and Danzer, CP and Gerlach, J and Nitschke, L. and Wirth, Thomas",
year = "2002",
abstract = "CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid. CD22 inhibits B cell receptor signaling. Mice deficient for CD22 show a largely normal B cell development. Here, we have performed a detailed analysis of the splenic B cell population and found that the subset of marginal zone (MZ) B cells was selectively reduced in CD22-deficient mice. CD22-deficient mice showed a lack of TNP-ficoll capturing cells in the MZ and a reduced response to TNP-ficoll, particularly when the antigen was applied intravenously. CD22-deficient B cells showed both enhanced motility as well as enhanced chemotaxis to certain chemokines. The altered chemokine responsiveness or the higher signaling capacity of CD22-deficient B cells may lead to the compromised MZ B cell compartment, as both processes have previously been shown to affect MZ composition.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "European Journal of Immunology",
title = "Reduction of marginal zone B cells in CD22-deficient mice",
pages = "567-561",
number = "2",
volume = "32",
doi = "10.1002/1521-4141(200202)32:2<561::AID-IMMU561>3.0.CO;2-H"
}