TY  - JOUR
AU  - Šobot, Vesna
AU  - Stamenković, Miroslav
AU  - Simić, Tatjana
AU  - Jerotić, Đurđa
AU  - Đokic, Milica
AU  - Jakšić, Vesna
AU  - Božić, Marija
AU  - Milić, Jovan
AU  - Savić-Radojević, Ana
AU  - Đukić, Tatjana
PY  - 2022
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/3947
AB  - It is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression
of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms
in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase
(SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single
nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as
GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102
POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both
GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and
SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni
multiple test correction (OR = 6.66, p = 0.005). The present study supports the hypothesis that in combination,
GSTO1/GSTO2, modulate the risk of primary open angle glaucoma.
PB  - Elsevier
PB  - Academic Press
PB  - International Society for Eye Research
T2  - Experimental Eye Research
T1  - Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma
SP  - 108863
VL  - 2014
DO  - 10.1016/j.exer.2021.108863
ER  - 

@article{
author = "Šobot, Vesna and Stamenković, Miroslav and Simić, Tatjana and Jerotić, Đurđa and Đokic, Milica and Jakšić, Vesna and Božić, Marija and Milić, Jovan and Savić-Radojević, Ana and Đukić, Tatjana",
year = "2022",
abstract = "It is becoming increasingly evident that oxidative stress has a supporting role in pathophysiology and progression
of primary open angle glaucoma (POAG). The aim of our study was to assess the association between polymorphisms
in genes encoding enzymes involved in redox homeostasis, mitochondrial superoxide dismutase
(SOD2), glutathione peroxidase (GPX1) and glutathione transferases (GSTs) with susceptibility to POAG. Single
nucleotide polymorphisms in GST omega (GSTO1rs4925, GSTO2 rs156697), pi 1 (GSTP1 rs1695), as well as
GPX1 (rs1050450) and SOD2 (rs4880) were determined by quantitative polymerase chain reaction (qPCR) in 102
POAG patients and 302 respective controls. The risk for POAG development was noted in carriers of both
GSTO2*GG and GSTO1*AA variant genotypes (OR = 8.21, p = 0.002). Individuals who carried GPX1*TT and
SOD2*CC genotypes had also an increased risk of POAG development but without significance after Bonferroni
multiple test correction (OR = 6.66, p = 0.005). The present study supports the hypothesis that in combination,
GSTO1/GSTO2, modulate the risk of primary open angle glaucoma.",
publisher = "Elsevier, Academic Press, International Society for Eye Research",
journal = "Experimental Eye Research",
title = "Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma",
pages = "108863",
volume = "2014",
doi = "10.1016/j.exer.2021.108863"
}

Šobot, V., Stamenković, M., Simić, T., Jerotić, Đ., Đokic, M., Jakšić, V., Božić, M., Milić, J., Savić-Radojević, A.,& Đukić, T.. (2022). Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. in Experimental Eye Research
Elsevier., 2014, 108863.
https://doi.org/10.1016/j.exer.2021.108863

Šobot V, Stamenković M, Simić T, Jerotić Đ, Đokic M, Jakšić V, Božić M, Milić J, Savić-Radojević A, Đukić T. Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma. in Experimental Eye Research. 2022;2014:108863.
doi:10.1016/j.exer.2021.108863 .

Šobot, Vesna, Stamenković, Miroslav, Simić, Tatjana, Jerotić, Đurđa, Đokic, Milica, Jakšić, Vesna, Božić, Marija, Milić, Jovan, Savić-Radojević, Ana, Đukić, Tatjana, "Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma" in Experimental Eye Research, 2014 (2022):108863,
https://doi.org/10.1016/j.exer.2021.108863 . .

TY  - JOUR
AU  - Senćanić, Ivan
AU  - Gazibara, Tatjana
AU  - Dotlić, Jelena
AU  - Stamenković, Miroslav
AU  - Jakšić, Vesna
AU  - Božić, Marija M.
AU  - Grgurević, Anita
PY  - 2019
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1205
AB  - Purpose The study aim was to translate and validate the Glaucoma Symptom Scale (GSS) in Serbian language. Methods Clinical parameters and socio-demographic data were collected for each of the 177 enrolled glaucoma patients. Each eye was classified according to the Glaucoma staging system by Mills into 6 stages. Patients filled out the GSS and National Eye Institute Visual Function Questionnaire (NEI-VFQ 25). The GSS comprises 10 complaints common for glaucoma patients on a topical treatment, grouped into two subscales: SYMP-6 (non-visual) and FUNC-4 (visual problems). The GSS was translated following the customary methodology and its psychometric properties were assessed by using both Classical Test Theory (CTT) and Rasch analysis. Results The internal consistency of the Serbian GSS for the whole scale was very good (Cronbach's alpha = 0.81). On factor analysis items were clustered into 2 factors (48.92% of variance) which corresponded to the original scale. The total and subscale GSS scores correlated significantly with measures of disease severity and also with total score and analogous NEI-VFQ 25 subscale scores. In Rasch analysis we obtained adequate item reliability index (0.90). Almost all items had infit and outfit mean squares in the accepted range. However, measurement precision was poor (low person separation reliability) and targeting revealed a ceiling effect. Conclusion When analyzed with CTT the Serbian version of the GSS seems to be a valid instrument, but Rasch analysis revealed some serious measurement flaws, therefore it should not be used in its current format. Further studies to modify and improve GSS are needed prior to its application for Serbian glaucoma patients.
PB  - Public Library Science, San Francisco
T2  - Plos One
T1  - Glaucoma Symptom Scale: Psychometric properties of the Serbian version
IS  - 5
VL  - 14
DO  - 10.1371/journal.pone.0216920
ER  - 

@article{
author = "Senćanić, Ivan and Gazibara, Tatjana and Dotlić, Jelena and Stamenković, Miroslav and Jakšić, Vesna and Božić, Marija M. and Grgurević, Anita",
year = "2019",
abstract = "Purpose The study aim was to translate and validate the Glaucoma Symptom Scale (GSS) in Serbian language. Methods Clinical parameters and socio-demographic data were collected for each of the 177 enrolled glaucoma patients. Each eye was classified according to the Glaucoma staging system by Mills into 6 stages. Patients filled out the GSS and National Eye Institute Visual Function Questionnaire (NEI-VFQ 25). The GSS comprises 10 complaints common for glaucoma patients on a topical treatment, grouped into two subscales: SYMP-6 (non-visual) and FUNC-4 (visual problems). The GSS was translated following the customary methodology and its psychometric properties were assessed by using both Classical Test Theory (CTT) and Rasch analysis. Results The internal consistency of the Serbian GSS for the whole scale was very good (Cronbach's alpha = 0.81). On factor analysis items were clustered into 2 factors (48.92% of variance) which corresponded to the original scale. The total and subscale GSS scores correlated significantly with measures of disease severity and also with total score and analogous NEI-VFQ 25 subscale scores. In Rasch analysis we obtained adequate item reliability index (0.90). Almost all items had infit and outfit mean squares in the accepted range. However, measurement precision was poor (low person separation reliability) and targeting revealed a ceiling effect. Conclusion When analyzed with CTT the Serbian version of the GSS seems to be a valid instrument, but Rasch analysis revealed some serious measurement flaws, therefore it should not be used in its current format. Further studies to modify and improve GSS are needed prior to its application for Serbian glaucoma patients.",
publisher = "Public Library Science, San Francisco",
journal = "Plos One",
title = "Glaucoma Symptom Scale: Psychometric properties of the Serbian version",
number = "5",
volume = "14",
doi = "10.1371/journal.pone.0216920"
}

Senćanić, I., Gazibara, T., Dotlić, J., Stamenković, M., Jakšić, V., Božić, M. M.,& Grgurević, A.. (2019). Glaucoma Symptom Scale: Psychometric properties of the Serbian version. in Plos One
Public Library Science, San Francisco., 14(5).
https://doi.org/10.1371/journal.pone.0216920

Senćanić I, Gazibara T, Dotlić J, Stamenković M, Jakšić V, Božić MM, Grgurević A. Glaucoma Symptom Scale: Psychometric properties of the Serbian version. in Plos One. 2019;14(5).
doi:10.1371/journal.pone.0216920 .

Senćanić, Ivan, Gazibara, Tatjana, Dotlić, Jelena, Stamenković, Miroslav, Jakšić, Vesna, Božić, Marija M., Grgurević, Anita, "Glaucoma Symptom Scale: Psychometric properties of the Serbian version" in Plos One, 14, no. 5 (2019),
https://doi.org/10.1371/journal.pone.0216920 . .

TY  - JOUR
AU  - Senćanić, Ivan
AU  - Gazibara, Tatjana
AU  - Dotlić, Jelena
AU  - Stamenković, Miroslav
AU  - Jakšić, Vesna
AU  - Božić, Marija M.
AU  - Grgurević, Anita
PY  - 2018
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1170
AB  - AIM: To translate the Glaucoma Quality of Life-15 (GQL-15) to Serbian language and asses its validity and reliability in the population of Serbian patients. METHODS: The study included 177 glaucoma patients. Clinical parameters (visual acuity, mean defect and square root of loss variance of visual field) and socio-demographic data were collected. Patients were stratified according to the Nelson's glaucoma staging system as mild, moderate and advanced glaucoma. All patients filled out the GQL-15 and National Eye Institute Visual Function Questionnaire (NEI-VFQ 25). The GQL-15 was translated following the internationally-accepted methodology, and its psychometric properties were assessed by using classical test theory and Rasch analysis. RESULTS: The mean total score for the GQL-15 was 20.68 +/- 7.31. The Cronbach's alpha coefficient for the whole scale was 0.89 (central and near vision, alpha=0.24; peripheral vision, alpha=0.85; glare and dark adaptation, alpha=0.83). Factor analysis established 4 factors (70.3% of variance): two corresponding to the original factors and two new factors specific for the Serbian population. The GQL-15 score correlated positively with almost all clinical parameters and NEI-VFQ 25 proving good criterion validity. Correlation of the GQL-15 total score on test-retest confirmed appropriate scale reproducibility (rho= 0.96, P lt 0.001). The GQL-15 discriminated well advanced from mild and moderate glaucoma. In Rasch analysis we obtained adequate item (0.95) reliability index. Almost all items had infit and outfit mean squares in the accepted range. CONCLUSION: Serbian version of the GQL-15 demonstrates adequate reliability and validity. This version of the GQL-15 is a valid instrument for evaluation of quality of life among Serbian speaking patients with glaucoma and can be applied in daily clinical work.
PB  - IJO Press, Xi An
T2  - International Journal of Ophthalmology
T1  - Validation of the Glaucoma Quality of Life-15 Questionnaire in Serbian language
EP  - 1684
IS  - 10
SP  - 1674
VL  - 11
DO  - 10.18240/ijo.2018.10.16
ER  - 

@article{
author = "Senćanić, Ivan and Gazibara, Tatjana and Dotlić, Jelena and Stamenković, Miroslav and Jakšić, Vesna and Božić, Marija M. and Grgurević, Anita",
year = "2018",
abstract = "AIM: To translate the Glaucoma Quality of Life-15 (GQL-15) to Serbian language and asses its validity and reliability in the population of Serbian patients. METHODS: The study included 177 glaucoma patients. Clinical parameters (visual acuity, mean defect and square root of loss variance of visual field) and socio-demographic data were collected. Patients were stratified according to the Nelson's glaucoma staging system as mild, moderate and advanced glaucoma. All patients filled out the GQL-15 and National Eye Institute Visual Function Questionnaire (NEI-VFQ 25). The GQL-15 was translated following the internationally-accepted methodology, and its psychometric properties were assessed by using classical test theory and Rasch analysis. RESULTS: The mean total score for the GQL-15 was 20.68 +/- 7.31. The Cronbach's alpha coefficient for the whole scale was 0.89 (central and near vision, alpha=0.24; peripheral vision, alpha=0.85; glare and dark adaptation, alpha=0.83). Factor analysis established 4 factors (70.3% of variance): two corresponding to the original factors and two new factors specific for the Serbian population. The GQL-15 score correlated positively with almost all clinical parameters and NEI-VFQ 25 proving good criterion validity. Correlation of the GQL-15 total score on test-retest confirmed appropriate scale reproducibility (rho= 0.96, P lt 0.001). The GQL-15 discriminated well advanced from mild and moderate glaucoma. In Rasch analysis we obtained adequate item (0.95) reliability index. Almost all items had infit and outfit mean squares in the accepted range. CONCLUSION: Serbian version of the GQL-15 demonstrates adequate reliability and validity. This version of the GQL-15 is a valid instrument for evaluation of quality of life among Serbian speaking patients with glaucoma and can be applied in daily clinical work.",
publisher = "IJO Press, Xi An",
journal = "International Journal of Ophthalmology",
title = "Validation of the Glaucoma Quality of Life-15 Questionnaire in Serbian language",
pages = "1684-1674",
number = "10",
volume = "11",
doi = "10.18240/ijo.2018.10.16"
}

Senćanić, I., Gazibara, T., Dotlić, J., Stamenković, M., Jakšić, V., Božić, M. M.,& Grgurević, A.. (2018). Validation of the Glaucoma Quality of Life-15 Questionnaire in Serbian language. in International Journal of Ophthalmology
IJO Press, Xi An., 11(10), 1674-1684.
https://doi.org/10.18240/ijo.2018.10.16

Senćanić I, Gazibara T, Dotlić J, Stamenković M, Jakšić V, Božić MM, Grgurević A. Validation of the Glaucoma Quality of Life-15 Questionnaire in Serbian language. in International Journal of Ophthalmology. 2018;11(10):1674-1684.
doi:10.18240/ijo.2018.10.16 .

Senćanić, Ivan, Gazibara, Tatjana, Dotlić, Jelena, Stamenković, Miroslav, Jakšić, Vesna, Božić, Marija M., Grgurević, Anita, "Validation of the Glaucoma Quality of Life-15 Questionnaire in Serbian language" in International Journal of Ophthalmology, 11, no. 10 (2018):1674-1684,
https://doi.org/10.18240/ijo.2018.10.16 . .

TY  - JOUR
AU  - Stamenković, Miroslav
AU  - Lukić, Vesna
AU  - Šuvakov, Sonja
AU  - Simić, Tatjana
AU  - Senćanić, Ivan
AU  - Plješa-Ercegovac, Marija
AU  - Jakšić, Vesna
AU  - Babović, Siniša
AU  - Matić, Marija
AU  - Radosavljević, Aleksandra
AU  - Savić-Radojević, Ana
AU  - Đukić, Tatjana
PY  - 2018
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1157
AB  - AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.
PB  - IJO Press, Xi An
T2  - International Journal of Ophthalmology
T1  - GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers
EP  - 1520
IS  - 9
SP  - 1514
VL  - 11
DO  - 10.18240/ijo.2018.09.14
ER  - 

@article{
author = "Stamenković, Miroslav and Lukić, Vesna and Šuvakov, Sonja and Simić, Tatjana and Senćanić, Ivan and Plješa-Ercegovac, Marija and Jakšić, Vesna and Babović, Siniša and Matić, Marija and Radosavljević, Aleksandra and Savić-Radojević, Ana and Đukić, Tatjana",
year = "2018",
abstract = "AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or chi(2) test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P lt 0.001; OR=4.53, P=0.002). CONCLUSION: The results obtained indicate that both GSTM1-null and GSTT1-active genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.",
publisher = "IJO Press, Xi An",
journal = "International Journal of Ophthalmology",
title = "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers",
pages = "1520-1514",
number = "9",
volume = "11",
doi = "10.18240/ijo.2018.09.14"
}

Stamenković, M., Lukić, V., Šuvakov, S., Simić, T., Senćanić, I., Plješa-Ercegovac, M., Jakšić, V., Babović, S., Matić, M., Radosavljević, A., Savić-Radojević, A.,& Đukić, T.. (2018). GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology
IJO Press, Xi An., 11(9), 1514-1520.
https://doi.org/10.18240/ijo.2018.09.14

Stamenković M, Lukić V, Šuvakov S, Simić T, Senćanić I, Plješa-Ercegovac M, Jakšić V, Babović S, Matić M, Radosavljević A, Savić-Radojević A, Đukić T. GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers. in International Journal of Ophthalmology. 2018;11(9):1514-1520.
doi:10.18240/ijo.2018.09.14 .

Stamenković, Miroslav, Lukić, Vesna, Šuvakov, Sonja, Simić, Tatjana, Senćanić, Ivan, Plješa-Ercegovac, Marija, Jakšić, Vesna, Babović, Siniša, Matić, Marija, Radosavljević, Aleksandra, Savić-Radojević, Ana, Đukić, Tatjana, "GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers" in International Journal of Ophthalmology, 11, no. 9 (2018):1514-1520,
https://doi.org/10.18240/ijo.2018.09.14 . .

TY  - JOUR
AU  - Živković, Maja
AU  - Jakšić, Vesna
AU  - Giarmoukakis, Athanassios
AU  - Grentzelos, Michael
AU  - Zlatanović, Marko
AU  - Zlatanović, Gordana
AU  - Miljković, Aleksandra
AU  - Jovanović, Svetlana
AU  - Stamenković, Miroslav
AU  - Kymionis, George
PY  - 2017
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1073
AB  - Purpose. To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. Methods. 89 patients (124 eyes) with established myopia range from -3.0 to -8.0 diopters and no associated ocular diseases were included in this study. RNFL and GC-IPL thickness measurements were performed by spectral domain optical coherence tomography (SD OCT) one day before LASIK and at 1 and 6 months postoperatively. Results. Mean RNFL thickness prior to LASIK was 93.86 +/- 12.17 mu m while the first month and the sixth month postoperatively were 94.01 +/- 12.04 mu m and 94.46 +/- 12.27 mu m, respectively. Comparing results, there is no significant difference between baseline, one month, and six months postoperatively for mean RNFL (p > 0.05). Mean GC-IPL thickness was 81.70 +/- 7.47 mu m preoperatively with no significant difference during the follow-up period (82.03 +/- 7.69 mu m versus 81.84 +/- 7.64 mu m; p > 0.05). Conclusion. RNFL and GC-IPL complex thickness remained unaffected following LASIK intervention.
PB  - Hindawi Ltd, London
T2  - Biomed Research International
T1  - The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes
VL  - 2017
DO  - 10.1155/2017/8923819
ER  - 

@article{
author = "Živković, Maja and Jakšić, Vesna and Giarmoukakis, Athanassios and Grentzelos, Michael and Zlatanović, Marko and Zlatanović, Gordana and Miljković, Aleksandra and Jovanović, Svetlana and Stamenković, Miroslav and Kymionis, George",
year = "2017",
abstract = "Purpose. To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. Methods. 89 patients (124 eyes) with established myopia range from -3.0 to -8.0 diopters and no associated ocular diseases were included in this study. RNFL and GC-IPL thickness measurements were performed by spectral domain optical coherence tomography (SD OCT) one day before LASIK and at 1 and 6 months postoperatively. Results. Mean RNFL thickness prior to LASIK was 93.86 +/- 12.17 mu m while the first month and the sixth month postoperatively were 94.01 +/- 12.04 mu m and 94.46 +/- 12.27 mu m, respectively. Comparing results, there is no significant difference between baseline, one month, and six months postoperatively for mean RNFL (p > 0.05). Mean GC-IPL thickness was 81.70 +/- 7.47 mu m preoperatively with no significant difference during the follow-up period (82.03 +/- 7.69 mu m versus 81.84 +/- 7.64 mu m; p > 0.05). Conclusion. RNFL and GC-IPL complex thickness remained unaffected following LASIK intervention.",
publisher = "Hindawi Ltd, London",
journal = "Biomed Research International",
title = "The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes",
volume = "2017",
doi = "10.1155/2017/8923819"
}

Živković, M., Jakšić, V., Giarmoukakis, A., Grentzelos, M., Zlatanović, M., Zlatanović, G., Miljković, A., Jovanović, S., Stamenković, M.,& Kymionis, G.. (2017). The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes. in Biomed Research International
Hindawi Ltd, London., 2017.
https://doi.org/10.1155/2017/8923819

Živković M, Jakšić V, Giarmoukakis A, Grentzelos M, Zlatanović M, Zlatanović G, Miljković A, Jovanović S, Stamenković M, Kymionis G. The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes. in Biomed Research International. 2017;2017.
doi:10.1155/2017/8923819 .

Živković, Maja, Jakšić, Vesna, Giarmoukakis, Athanassios, Grentzelos, Michael, Zlatanović, Marko, Zlatanović, Gordana, Miljković, Aleksandra, Jovanović, Svetlana, Stamenković, Miroslav, Kymionis, George, "The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes" in Biomed Research International, 2017 (2017),
https://doi.org/10.1155/2017/8923819 . .

TY  - JOUR
AU  - Stamenković, Miroslav
AU  - Radić, Tanja
AU  - Stefanović, Ivan
AU  - Corić, Vesna
AU  - Senćanić, Ivan
AU  - Plješa-Ercegovac, Marija
AU  - Matić, Marija
AU  - Jakšić, Vesna
AU  - Simić, Tatjana
AU  - Savić-Radojević, Ana
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/868
AB  - Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.
PB  - Wiley-Blackwell, Hoboken
T2  - Clinical and Experimental Ophthalmology
T1  - Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation
EP  - 283
IS  - 3
SP  - 277
VL  - 42
DO  - 10.1111/ceo.12180
ER  - 

@article{
author = "Stamenković, Miroslav and Radić, Tanja and Stefanović, Ivan and Corić, Vesna and Senćanić, Ivan and Plješa-Ercegovac, Marija and Matić, Marija and Jakšić, Vesna and Simić, Tatjana and Savić-Radojević, Ana",
year = "2014",
abstract = "Background Glutathione S-transferase omega-1 and 2 have a unique range of enzymatic activities, including the regeneration of ascorbate by their dehydroascorbate reductase activities. Because these enzymes could have a protective role from oxidative damage in the lens, the question of whether the two coding glutathione S-transferase omega polymorphisms confer the risk of age-related cataract was addressed. Methods rs4925 (Ala140Asp) of glutathione S-transferase omega-1 and rs156697 (Asn142Asp) of glutathione S-transferase omega-2 polymorphisms in 100 patients with age-related cataract and 130 controls were assessed. Results Presence of one mutant GSTO1*Asp or GSTO2*Asp allele did not contribute independently towards the risk of cataract; however, homozygous carriers of GSTO1*Asp/GSTO2*Asp haplotype demonstrated 3.42-fold enhanced risk of cataract development (95% confidence interval = 0.84-13.93; P = 0.086). When GSTO genotype was analysed in association with smoking or professional exposure to ultraviolet irradiation, carriers of at least one mutant GSTO2*Asp allele had increased risk of cataract development in comparison with individuals with wild-type GSTO2*Asn/Asn with no history of smoking or ultraviolet exposure (odds ratio = 6.89, 95% confidence interval = 1.81-16.21, P = 0.005; odds ratio = 4.10, 95% confidence interval = 1.23-13.74, P = 0.022, respectively). Regarding the distribution of particular glutathione S-transferase omega genotype and cataract type, the highest frequency of mutant GSTO2*Asp allele was found in patients with nuclear cataract. Conclusion The results indicate that mutant GSTO2*Asp genotype is associated with increased risk of age-related cataract in smokers and ultraviolet-exposed subjects, suggesting a role of inefficient ascorbate regeneration in cataract development.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Clinical and Experimental Ophthalmology",
title = "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation",
pages = "283-277",
number = "3",
volume = "42",
doi = "10.1111/ceo.12180"
}

Stamenković, M., Radić, T., Stefanović, I., Corić, V., Senćanić, I., Plješa-Ercegovac, M., Matić, M., Jakšić, V., Simić, T.,& Savić-Radojević, A.. (2014). Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology
Wiley-Blackwell, Hoboken., 42(3), 277-283.
https://doi.org/10.1111/ceo.12180

Stamenković M, Radić T, Stefanović I, Corić V, Senćanić I, Plješa-Ercegovac M, Matić M, Jakšić V, Simić T, Savić-Radojević A. Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. in Clinical and Experimental Ophthalmology. 2014;42(3):277-283.
doi:10.1111/ceo.12180 .

Stamenković, Miroslav, Radić, Tanja, Stefanović, Ivan, Corić, Vesna, Senćanić, Ivan, Plješa-Ercegovac, Marija, Matić, Marija, Jakšić, Vesna, Simić, Tatjana, Savić-Radojević, Ana, "Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation" in Clinical and Experimental Ophthalmology, 42, no. 3 (2014):277-283,
https://doi.org/10.1111/ceo.12180 . .

TY  - JOUR
AU  - Senćanić, Ivan
AU  - Stamenković, Miroslav
AU  - Jovanović, Vesna
AU  - Babović, Siniša
AU  - Jakšić, Vesna
AU  - Marković, Petar
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/776
AB  - Ultrastrukturne promene rožnjače kod osoba obolelih od dijabetes melitusa (DM) opisane su u ranijim radovima. Cilj istraživanja je bio poređenje centralne debljine rožnjače (CDR) osoba obolelih od DM bez retinopatije u stadijumu neproliferativne i proliferativne dijabetičke retinopa-tije sa CDR zdravih osoba kontrolne grupe.
Metode rada: Ukupno je ispitana 121 osoba sa DM i 125 zdravih osoba. Kontrolnu grupu su činile osobe individualno uparene prema polu i starosti sa bolesnicima iz studijske grupe. Svi ispitanici su podvrgnuti oftalmološkom pregledu, koji je obuhvatio pregled očnog dna i merenje CDR ultrazvučnim pahimetrom. Oči ispitanika sa DM su, prema kriterijumima Early Treatment Diabetic Retinopathy Study, podeljene u tri grupe: grupu bez dijabetičke retinopatije (NDR), sa neprolife-rativnom dijabetičkom retinopatijom (NPDR) i proliferativnom dijabetičkom retinopatijom (PDR). U istraživanje je uključeno samo jedno oko svakog ispitanika. 
Rezultati: Prosečna vrednost CDR bolesnika sa DM bila je 570,52±31,81 μm, a zdravih ispitanika 541,42±27,82 μm. Razlika u CDR između dve posmatrane grupe bila je statistički visoko značajna (p<0,0001). Najveća prosečna vrednost CDR izmerena je u grupi PDR (585,97±28,58 μm), potom u grupi NPDR (570,84±30,27 μm), a naposletku u grupi NDR (559,80±31,55 μm). Statistički značajna razlika zabeležena je između grupa NDR i PDR (p<0,001), kao i grupa NPDR i PDR (p<0,05). Razlika između grupa NDR i NPDR nije bila statistički značajna (p>0,05).
Zaključak: Veća CDR je utvrđena kod osoba sa DM u poređenju sa zdravim ispitanicima. Najveća CDR je ustanovljena u grupi očiju sa PDR; slede grupe NPDR i NDR.
AB  - Introduction Ultrastructural changes in corneas of patients with diabetes mellitus have been previously described. Objective The aim of this study was to compare central corneal thickness (CDR) values in diabetic patients without retinopathy at the stage of diabetic nonproliferative and proliferative retinopathy and CDR in a control group of healthy subjects. Methods The study included 121 diabetic patients and 125 healthy subjects matched according to gender and age. Each patient underwent ophthalmological examination involving a dilated fundus examination and CDR measurement using the ultrasound pachymeter. The eyes of diabetic patients were classified according to Early Treatment Diabetic Retinopathy Study into three groups: without diabetic retinopathy (NDR), with nonproliferative diabetic retinopathy (NPDR) and a group with proliferative diabetic retinopathy (PDR). Only one eye of each subject was chosen for the study. Results The mean CDR value was significantly higher in the diabetic group (570.52 +/- 31.81 mu m) compared with the control group (541.42 +/- 27.82 mu m). The difference between the two groups was statistically significant (p lt 0.0001). The highest mean CDR value was recorded in the PDR group (585.97 +/- 28.58 mu m), followed by the NPDR group (570.84 +/- 30.27 mu m), whereas the lowest mean CDR value was recorded in the NDR group (559.80 +/- 31.55 mu m). There was a statistically significant difference in CDR between the NDR and PDR groups, as well as between the NPDR and PDR groups (p lt 0.001, p lt 0.05 respectively). No significant difference was recorded between the NDR and NPDR groups (p>0.05). Conclusion CDR of diabetic patients was higher compared to healthy subjects. The highest mean value of CDR was registered in the PDR group, followed by the NPDR and the NDR groups.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Uticaj dijabetes melitusa na debljinu rožnjače
T1  - Influence of Diabetes Mellitus on Corneal Thickness
EP  - 534
IS  - 9-10
SP  - 529
VL  - 142
DO  - 10.2298/SARH1410529S
ER  - 

@article{
author = "Senćanić, Ivan and Stamenković, Miroslav and Jovanović, Vesna and Babović, Siniša and Jakšić, Vesna and Marković, Petar",
year = "2014",
abstract = "Ultrastrukturne promene rožnjače kod osoba obolelih od dijabetes melitusa (DM) opisane su u ranijim radovima. Cilj istraživanja je bio poređenje centralne debljine rožnjače (CDR) osoba obolelih od DM bez retinopatije u stadijumu neproliferativne i proliferativne dijabetičke retinopa-tije sa CDR zdravih osoba kontrolne grupe.
Metode rada: Ukupno je ispitana 121 osoba sa DM i 125 zdravih osoba. Kontrolnu grupu su činile osobe individualno uparene prema polu i starosti sa bolesnicima iz studijske grupe. Svi ispitanici su podvrgnuti oftalmološkom pregledu, koji je obuhvatio pregled očnog dna i merenje CDR ultrazvučnim pahimetrom. Oči ispitanika sa DM su, prema kriterijumima Early Treatment Diabetic Retinopathy Study, podeljene u tri grupe: grupu bez dijabetičke retinopatije (NDR), sa neprolife-rativnom dijabetičkom retinopatijom (NPDR) i proliferativnom dijabetičkom retinopatijom (PDR). U istraživanje je uključeno samo jedno oko svakog ispitanika. 
Rezultati: Prosečna vrednost CDR bolesnika sa DM bila je 570,52±31,81 μm, a zdravih ispitanika 541,42±27,82 μm. Razlika u CDR između dve posmatrane grupe bila je statistički visoko značajna (p<0,0001). Najveća prosečna vrednost CDR izmerena je u grupi PDR (585,97±28,58 μm), potom u grupi NPDR (570,84±30,27 μm), a naposletku u grupi NDR (559,80±31,55 μm). Statistički značajna razlika zabeležena je između grupa NDR i PDR (p<0,001), kao i grupa NPDR i PDR (p<0,05). Razlika između grupa NDR i NPDR nije bila statistički značajna (p>0,05).
Zaključak: Veća CDR je utvrđena kod osoba sa DM u poređenju sa zdravim ispitanicima. Najveća CDR je ustanovljena u grupi očiju sa PDR; slede grupe NPDR i NDR., Introduction Ultrastructural changes in corneas of patients with diabetes mellitus have been previously described. Objective The aim of this study was to compare central corneal thickness (CDR) values in diabetic patients without retinopathy at the stage of diabetic nonproliferative and proliferative retinopathy and CDR in a control group of healthy subjects. Methods The study included 121 diabetic patients and 125 healthy subjects matched according to gender and age. Each patient underwent ophthalmological examination involving a dilated fundus examination and CDR measurement using the ultrasound pachymeter. The eyes of diabetic patients were classified according to Early Treatment Diabetic Retinopathy Study into three groups: without diabetic retinopathy (NDR), with nonproliferative diabetic retinopathy (NPDR) and a group with proliferative diabetic retinopathy (PDR). Only one eye of each subject was chosen for the study. Results The mean CDR value was significantly higher in the diabetic group (570.52 +/- 31.81 mu m) compared with the control group (541.42 +/- 27.82 mu m). The difference between the two groups was statistically significant (p lt 0.0001). The highest mean CDR value was recorded in the PDR group (585.97 +/- 28.58 mu m), followed by the NPDR group (570.84 +/- 30.27 mu m), whereas the lowest mean CDR value was recorded in the NDR group (559.80 +/- 31.55 mu m). There was a statistically significant difference in CDR between the NDR and PDR groups, as well as between the NPDR and PDR groups (p lt 0.001, p lt 0.05 respectively). No significant difference was recorded between the NDR and NPDR groups (p>0.05). Conclusion CDR of diabetic patients was higher compared to healthy subjects. The highest mean value of CDR was registered in the PDR group, followed by the NPDR and the NDR groups.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Uticaj dijabetes melitusa na debljinu rožnjače, Influence of Diabetes Mellitus on Corneal Thickness",
pages = "534-529",
number = "9-10",
volume = "142",
doi = "10.2298/SARH1410529S"
}

Senćanić, I., Stamenković, M., Jovanović, V., Babović, S., Jakšić, V.,& Marković, P.. (2014). Uticaj dijabetes melitusa na debljinu rožnjače. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 142(9-10), 529-534.
https://doi.org/10.2298/SARH1410529S

Senćanić I, Stamenković M, Jovanović V, Babović S, Jakšić V, Marković P. Uticaj dijabetes melitusa na debljinu rožnjače. in Srpski arhiv za celokupno lekarstvo. 2014;142(9-10):529-534.
doi:10.2298/SARH1410529S .

Senćanić, Ivan, Stamenković, Miroslav, Jovanović, Vesna, Babović, Siniša, Jakšić, Vesna, Marković, Petar, "Uticaj dijabetes melitusa na debljinu rožnjače" in Srpski arhiv za celokupno lekarstvo, 142, no. 9-10 (2014):529-534,
https://doi.org/10.2298/SARH1410529S . .