TY  - JOUR
AU  - Veselinović, Nikola
AU  - Pavlović, Aleksandra M.
AU  - Petrović, Boris
AU  - Ristić, Aleksandar
AU  - Novaković, Ivana
AU  - Svabic-Medjedović, Tamara
AU  - Pavlović, Dragan
AU  - Šternić, Nadežda
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/863
AB  - Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Cognitive and Behavioral Neurology
T1  - Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease
EP  - 50
IS  - 1
SP  - 48
VL  - 27
DO  - 10.1097/WNN.0000000000000015
ER  - 

@article{
author = "Veselinović, Nikola and Pavlović, Aleksandra M. and Petrović, Boris and Ristić, Aleksandar and Novaković, Ivana and Svabic-Medjedović, Tamara and Pavlović, Dragan and Šternić, Nadežda",
year = "2014",
abstract = "Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Cognitive and Behavioral Neurology",
title = "Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease",
pages = "50-48",
number = "1",
volume = "27",
doi = "10.1097/WNN.0000000000000015"
}

Veselinović, N., Pavlović, A. M., Petrović, B., Ristić, A., Novaković, I., Svabic-Medjedović, T., Pavlović, D.,& Šternić, N.. (2014). Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease. in Cognitive and Behavioral Neurology
Lippincott Williams & Wilkins, Philadelphia., 27(1), 48-50.
https://doi.org/10.1097/WNN.0000000000000015

Veselinović N, Pavlović AM, Petrović B, Ristić A, Novaković I, Svabic-Medjedović T, Pavlović D, Šternić N. Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease. in Cognitive and Behavioral Neurology. 2014;27(1):48-50.
doi:10.1097/WNN.0000000000000015 .

Veselinović, Nikola, Pavlović, Aleksandra M., Petrović, Boris, Ristić, Aleksandar, Novaković, Ivana, Svabic-Medjedović, Tamara, Pavlović, Dragan, Šternić, Nadežda, "Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease" in Cognitive and Behavioral Neurology, 27, no. 1 (2014):48-50,
https://doi.org/10.1097/WNN.0000000000000015 . .

TY  - JOUR
AU  - Pavlović, Aleksandra M.
AU  - Pavlović, Dragan
AU  - Aleksić, Vuk
AU  - Šternić, Nadežda
PY  - 2013
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/709
AB  - Vascular dementia (VaD) is the second most frequent dementia after Alzheimer's disease, and is diagnosed during lifetime in 20% of demented patients. Five­year survival rate in VaD is 39%, while it is estimated to be 75% in healthy persons of the same age. It is therefore important to make correct diagnosis of VaD early in the course of the disease. Risk factors for VaD are identical to stroke risk factors, and there are significant possibilities for the prevention of vascular cognitive decline. Cognitive decline develops acutely or step­by­step within three months after stroke, but more gradual progression of intellectual decline is also possible. Neurological examination can reveal pyramidal and extrapyramidal signs, pseudobulbar palsy, gait disturbance and urinary incontinence. Neuropsychological profile comprises the loss of cognitive set shifting, decline in word fluency, verbal learning difficulties, perseverations, difficulties in complex figure copying, and in patients with cortically located lesions also problems with speech and praxia. The basis of the diagnosis is, besides history, neurological examination and neuropsychological assessment, computed tomography and/ or magnetic resonance brain imaging. Vascular risk factors control is the most important measure in VaD prevention. Modern guidelines for the treatment of cognitive decline in VaD emphasize that donepezil can be useful in the improvement of cognitive status at the level of Class IIa recommendation at the level of evidence A, while memantine may be useful in patients with mixed VaD and Alzheimer's disease dementia.
AB  - Vaskularna demencija (VaD) je posle Alchajmerove bolesti druga po učestalosti demencija, koja se zaživotno dijagnostikuje kod oko 20% svih dementnih bolesnika. Petogodišnje preživljavanje obolelih od VaD je 39%, u odnosu na 75% zdravih osoba istog životnog doba. Zbog toga je veoma važno pravovremeno i tačno postaviti dijagnozu VaD. Faktori rizika za nastanak VaD su istovetni onima za moždani udar, te postoje značajne mogućnosti za prevenciju vaskularnog kognitivnog pada. Kognitivni pad se ispoljava naglo ili postepeno tokom tri meseca od moždanog udara, ali je moguće i tzv. šunjajuće napredovanje intelektualnog propadanja. U neurološkom nalazu se mogu naći piramidalni i ekstrapiramidalni znaci, pseudobulbarna paraliza, poremećaji hodanja i inkontinencija urina. Neuropsihološki profil obuhvata teškoće promene kognitivnog seta, pogoršanje fonemske fluentnosti, oštećenje verbalnog učenja, perseverativnost, teškoće kopiranja složenog crteža, a kod kortikalno lociranih lezija i smetnje govora i praksije. Osnova dijagnoze je, pored anamneze, neurološkog pregleda i neuropsihološkog ispitivanja, nalaz na snimcima mozga skenerom i/ili magnetnom rezonancijom. Kontrola vaskularnih faktora rizika je najznačajnija mera u prevenciji VaD. Savremene preporuke za lečenje bolesnika sa VaD ističu da donepezil može biti koristan za poboljšanje kognitivnog stanja bolesnika sa VaD na nivou klase IIa preporuka, nivoa dokaza A, dok memantin može biti koristan kod bolesnika s mešovitom VaD, s elementima Alchajmerove bolesti.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Vascular dementia: Facts and controversies
T1  - Vaskularna demencija - istine i kontroverze
EP  - 255
IS  - 3-4
SP  - 247
VL  - 141
DO  - 10.2298/SARH1304247P
ER  - 

@article{
author = "Pavlović, Aleksandra M. and Pavlović, Dragan and Aleksić, Vuk and Šternić, Nadežda",
year = "2013",
abstract = "Vascular dementia (VaD) is the second most frequent dementia after Alzheimer's disease, and is diagnosed during lifetime in 20% of demented patients. Five­year survival rate in VaD is 39%, while it is estimated to be 75% in healthy persons of the same age. It is therefore important to make correct diagnosis of VaD early in the course of the disease. Risk factors for VaD are identical to stroke risk factors, and there are significant possibilities for the prevention of vascular cognitive decline. Cognitive decline develops acutely or step­by­step within three months after stroke, but more gradual progression of intellectual decline is also possible. Neurological examination can reveal pyramidal and extrapyramidal signs, pseudobulbar palsy, gait disturbance and urinary incontinence. Neuropsychological profile comprises the loss of cognitive set shifting, decline in word fluency, verbal learning difficulties, perseverations, difficulties in complex figure copying, and in patients with cortically located lesions also problems with speech and praxia. The basis of the diagnosis is, besides history, neurological examination and neuropsychological assessment, computed tomography and/ or magnetic resonance brain imaging. Vascular risk factors control is the most important measure in VaD prevention. Modern guidelines for the treatment of cognitive decline in VaD emphasize that donepezil can be useful in the improvement of cognitive status at the level of Class IIa recommendation at the level of evidence A, while memantine may be useful in patients with mixed VaD and Alzheimer's disease dementia., Vaskularna demencija (VaD) je posle Alchajmerove bolesti druga po učestalosti demencija, koja se zaživotno dijagnostikuje kod oko 20% svih dementnih bolesnika. Petogodišnje preživljavanje obolelih od VaD je 39%, u odnosu na 75% zdravih osoba istog životnog doba. Zbog toga je veoma važno pravovremeno i tačno postaviti dijagnozu VaD. Faktori rizika za nastanak VaD su istovetni onima za moždani udar, te postoje značajne mogućnosti za prevenciju vaskularnog kognitivnog pada. Kognitivni pad se ispoljava naglo ili postepeno tokom tri meseca od moždanog udara, ali je moguće i tzv. šunjajuće napredovanje intelektualnog propadanja. U neurološkom nalazu se mogu naći piramidalni i ekstrapiramidalni znaci, pseudobulbarna paraliza, poremećaji hodanja i inkontinencija urina. Neuropsihološki profil obuhvata teškoće promene kognitivnog seta, pogoršanje fonemske fluentnosti, oštećenje verbalnog učenja, perseverativnost, teškoće kopiranja složenog crteža, a kod kortikalno lociranih lezija i smetnje govora i praksije. Osnova dijagnoze je, pored anamneze, neurološkog pregleda i neuropsihološkog ispitivanja, nalaz na snimcima mozga skenerom i/ili magnetnom rezonancijom. Kontrola vaskularnih faktora rizika je najznačajnija mera u prevenciji VaD. Savremene preporuke za lečenje bolesnika sa VaD ističu da donepezil može biti koristan za poboljšanje kognitivnog stanja bolesnika sa VaD na nivou klase IIa preporuka, nivoa dokaza A, dok memantin može biti koristan kod bolesnika s mešovitom VaD, s elementima Alchajmerove bolesti.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Vascular dementia: Facts and controversies, Vaskularna demencija - istine i kontroverze",
pages = "255-247",
number = "3-4",
volume = "141",
doi = "10.2298/SARH1304247P"
}

Pavlović, A. M., Pavlović, D., Aleksić, V.,& Šternić, N.. (2013). Vascular dementia: Facts and controversies. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 141(3-4), 247-255.
https://doi.org/10.2298/SARH1304247P

Pavlović AM, Pavlović D, Aleksić V, Šternić N. Vascular dementia: Facts and controversies. in Srpski arhiv za celokupno lekarstvo. 2013;141(3-4):247-255.
doi:10.2298/SARH1304247P .

Pavlović, Aleksandra M., Pavlović, Dragan, Aleksić, Vuk, Šternić, Nadežda, "Vascular dementia: Facts and controversies" in Srpski arhiv za celokupno lekarstvo, 141, no. 3-4 (2013):247-255,
https://doi.org/10.2298/SARH1304247P . .