TY  - JOUR
AU  - Veselinović, Nikola
AU  - Pavlović, Aleksandra M.
AU  - Petrović, Boris
AU  - Ristić, Aleksandar
AU  - Novaković, Ivana
AU  - Svabic-Medjedović, Tamara
AU  - Pavlović, Dragan
AU  - Šternić, Nadežda
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/863
AB  - Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Cognitive and Behavioral Neurology
T1  - Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease
EP  - 50
IS  - 1
SP  - 48
VL  - 27
DO  - 10.1097/WNN.0000000000000015
ER  - 

@article{
author = "Veselinović, Nikola and Pavlović, Aleksandra M. and Petrović, Boris and Ristić, Aleksandar and Novaković, Ivana and Svabic-Medjedović, Tamara and Pavlović, Dragan and Šternić, Nadežda",
year = "2014",
abstract = "Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by conformational alteration of the ubiquitous prion protein. Sporadic CJD appears to progress faster if the basal ganglia are shown to be affected on magnetic resonance imaging. Transcranial B-mode sonography (TCS) enables visualization of differences in tissue echogenicity, which can be associated with changes in the cerebral metabolism of various metals. These metabolic changes are considered 1 of the potential mechanisms of the brain damage in CJD; TCS hyperechogenicity may reflect changes in metal homeostasis in CJD. We report a 63-year-old woman who presented with typical sporadic CJD. One month after she fell ill, a magnetic resonance imaging scan of her brain showed diffuse cortical but no obvious basal ganglia involvement. However, TCS revealed moderate hyperechogenicity of both lentiform nuclei. The patient's disease progressed quickly and she died 2 months later. TCS may show basal ganglia alteration early in the disease course of patients with quickly progressing CJD, thus aiding in premortem diagnosis.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Cognitive and Behavioral Neurology",
title = "Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease",
pages = "50-48",
number = "1",
volume = "27",
doi = "10.1097/WNN.0000000000000015"
}

Veselinović, N., Pavlović, A. M., Petrović, B., Ristić, A., Novaković, I., Svabic-Medjedović, T., Pavlović, D.,& Šternić, N.. (2014). Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease. in Cognitive and Behavioral Neurology
Lippincott Williams & Wilkins, Philadelphia., 27(1), 48-50.
https://doi.org/10.1097/WNN.0000000000000015

Veselinović N, Pavlović AM, Petrović B, Ristić A, Novaković I, Svabic-Medjedović T, Pavlović D, Šternić N. Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease. in Cognitive and Behavioral Neurology. 2014;27(1):48-50.
doi:10.1097/WNN.0000000000000015 .

Veselinović, Nikola, Pavlović, Aleksandra M., Petrović, Boris, Ristić, Aleksandar, Novaković, Ivana, Svabic-Medjedović, Tamara, Pavlović, Dragan, Šternić, Nadežda, "Altered Basal Ganglia Echogenicity Early in Sporadic Creutzfeldt-Jakob Disease" in Cognitive and Behavioral Neurology, 27, no. 1 (2014):48-50,
https://doi.org/10.1097/WNN.0000000000000015 . .