TY  - CONF
AU  - Marinkovic, Tatjana
AU  - Marinkovic, Dragan
PY  - 2023
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5176
AB  - The rate of cognitive and emotional dysfunction is increasing in the modern society, therefore nutritional impact on the
brain functioning is receiving higher attention in science and practice. In order to summarize the latest scientific knowledge
concerning nutritional impact on the nervous system and particularly on the brain functioning we performed literature search and
analysis. Increasing number of scientific data show that macronutrients and micronutrients (vitamins and minerals) affect multiple
brain processes through control of diverse mechanisms as: synaptic transmission, neurotransmitter pathways, signal-transduction
pathways, membrane fluidity, epigenetic changes, etc. Impact of specific macronutrients and micronutrients in brain functioning and
their food source is presented in details. We believe that these data might be of interest to wide spectrum of professionals as:
physicians, nutritionists, psychologists, neuroscientists etc.
PB  - Western Serbia Academy of Applied Studies
C3  - 13th International Scientific Conference “Science and High Education in Function of Sustainable Development
T1  - Nutritional impact on brain function: Food for thought, emotions and wellbeing
EP  - 5.84
SP  - 5.57
UR  - https://hdl.handle.net/21.15107/rcub_rfasper_5176
ER  - 

@conference{
author = "Marinkovic, Tatjana and Marinkovic, Dragan",
year = "2023",
abstract = "The rate of cognitive and emotional dysfunction is increasing in the modern society, therefore nutritional impact on the
brain functioning is receiving higher attention in science and practice. In order to summarize the latest scientific knowledge
concerning nutritional impact on the nervous system and particularly on the brain functioning we performed literature search and
analysis. Increasing number of scientific data show that macronutrients and micronutrients (vitamins and minerals) affect multiple
brain processes through control of diverse mechanisms as: synaptic transmission, neurotransmitter pathways, signal-transduction
pathways, membrane fluidity, epigenetic changes, etc. Impact of specific macronutrients and micronutrients in brain functioning and
their food source is presented in details. We believe that these data might be of interest to wide spectrum of professionals as:
physicians, nutritionists, psychologists, neuroscientists etc.",
publisher = "Western Serbia Academy of Applied Studies",
journal = "13th International Scientific Conference “Science and High Education in Function of Sustainable Development",
title = "Nutritional impact on brain function: Food for thought, emotions and wellbeing",
pages = "5.84-5.57",
url = "https://hdl.handle.net/21.15107/rcub_rfasper_5176"
}

Marinkovic, T.,& Marinkovic, D.. (2023). Nutritional impact on brain function: Food for thought, emotions and wellbeing. in 13th International Scientific Conference “Science and High Education in Function of Sustainable Development
Western Serbia Academy of Applied Studies., 5.57-5.84.
https://hdl.handle.net/21.15107/rcub_rfasper_5176

Marinkovic T, Marinkovic D. Nutritional impact on brain function: Food for thought, emotions and wellbeing. in 13th International Scientific Conference “Science and High Education in Function of Sustainable Development. 2023;:5.57-5.84.
https://hdl.handle.net/21.15107/rcub_rfasper_5176 .

Marinkovic, Tatjana, Marinkovic, Dragan, "Nutritional impact on brain function: Food for thought, emotions and wellbeing" in 13th International Scientific Conference “Science and High Education in Function of Sustainable Development (2023):5.57-5.84,
https://hdl.handle.net/21.15107/rcub_rfasper_5176 .

TY  - JOUR
AU  - Yalcin, Safak
AU  - Marinkovic, Dragan
AU  - Mungamuri, Sathish Kumar
AU  - Zhang, Xin
AU  - Tong, Wei
AU  - Sellers, Rani
AU  - Ghaffari, Saghi
PY  - 2010
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/5178
AB  - Reactive oxygen species (ROS) participate in normal intracellular signalling and in many diseases including cancer and aging, although the associated mechanisms are not fully understood. Forkhead Box O (FoxO) 3 transcription factor regulates levels of ROS concentrations, and is essential for maintenance of hematopoietic stem cells. Here, we show that loss of Foxo3 causes a myeloproliferative syndrome with splenomegaly and increased hematopoietic progenitors (HPs) that are hypersensitive to cytokines. These mutant HPs contain increased ROS, overactive intracellular signalling through the AKT/mammalian target of rapamycin signalling pathway and relative deficiency of Lnk, a negative regulator of cytokine receptor signalling. In vivo treatment with ROS scavenger N-acetyl-cysteine corrects these biochemical abnormalities and relieves the myeloproliferation. Moreover, enforced expression of Lnk by retroviral transfer corrects the abnormal expansion of Foxo3(-/-) HPs in vivo. Our combined results show that loss of Foxo3 causes increased ROS accumulation in HPs. In turn, this inhibits Lnk expression that contributes to exaggerated cytokine responses that lead to myeloproliferation. Our findings could explain the mechanisms by which mutations that alter Foxo3 function induce malignancy. More generally, the work illustrates how deregulated ROS may contribute to malignant progression.
PB  - The EMBO Journal
T2  - The EMBO Journal
T1  - ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice
EP  - 4131
IS  - 24
SP  - 4118
VL  - 29
DO  - 10.1038/emboj.2010.292
ER  - 

@article{
author = "Yalcin, Safak and Marinkovic, Dragan and Mungamuri, Sathish Kumar and Zhang, Xin and Tong, Wei and Sellers, Rani and Ghaffari, Saghi",
year = "2010",
abstract = "Reactive oxygen species (ROS) participate in normal intracellular signalling and in many diseases including cancer and aging, although the associated mechanisms are not fully understood. Forkhead Box O (FoxO) 3 transcription factor regulates levels of ROS concentrations, and is essential for maintenance of hematopoietic stem cells. Here, we show that loss of Foxo3 causes a myeloproliferative syndrome with splenomegaly and increased hematopoietic progenitors (HPs) that are hypersensitive to cytokines. These mutant HPs contain increased ROS, overactive intracellular signalling through the AKT/mammalian target of rapamycin signalling pathway and relative deficiency of Lnk, a negative regulator of cytokine receptor signalling. In vivo treatment with ROS scavenger N-acetyl-cysteine corrects these biochemical abnormalities and relieves the myeloproliferation. Moreover, enforced expression of Lnk by retroviral transfer corrects the abnormal expansion of Foxo3(-/-) HPs in vivo. Our combined results show that loss of Foxo3 causes increased ROS accumulation in HPs. In turn, this inhibits Lnk expression that contributes to exaggerated cytokine responses that lead to myeloproliferation. Our findings could explain the mechanisms by which mutations that alter Foxo3 function induce malignancy. More generally, the work illustrates how deregulated ROS may contribute to malignant progression.",
publisher = "The EMBO Journal",
journal = "The EMBO Journal",
title = "ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice",
pages = "4131-4118",
number = "24",
volume = "29",
doi = "10.1038/emboj.2010.292"
}

Yalcin, S., Marinkovic, D., Mungamuri, S. K., Zhang, X., Tong, W., Sellers, R.,& Ghaffari, S.. (2010). ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. in The EMBO Journal
The EMBO Journal., 29(24), 4118-4131.
https://doi.org/10.1038/emboj.2010.292

Yalcin S, Marinkovic D, Mungamuri SK, Zhang X, Tong W, Sellers R, Ghaffari S. ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. in The EMBO Journal. 2010;29(24):4118-4131.
doi:10.1038/emboj.2010.292 .

Yalcin, Safak, Marinkovic, Dragan, Mungamuri, Sathish Kumar, Zhang, Xin, Tong, Wei, Sellers, Rani, Ghaffari, Saghi, "ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice" in The EMBO Journal, 29, no. 24 (2010):4118-4131,
https://doi.org/10.1038/emboj.2010.292 . .