TY  - JOUR
AU  - Milovanović, Maja
AU  - Radivojević, Vlada
AU  - Radosavljev-Kirćanski, Jelena
AU  - Grujicić, Roberto
AU  - Tošković, Oliver
AU  - Aleksić-Hil, Olivera
AU  - Pejović-Milovančević, Milica
PY  - 2019
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1203
AB  - Purpose: The purpose of this study was to determine the prevalence of epilepsy and subclinical epileptiform abnormalities in children with autism spectrum disorder (ASD), and to investigate its effects on core autistic symptoms and adaptive behavior skills. Methods: Patients with diagnosis of ASD who met full criteria on Autism Diagnostic Interview-Revised (ADI-R) were included in the study. Adaptive behavior skills were assessed by Vineland Adaptive Behavior Scale-II (VABS-II). Clinical assessment for epilepsy and video electroencephalography (EEG) (v-EEG) examinations during wakefulness and/or sleep were prospectively performed in all patients. Results: A total of 112 patients with diagnosis of ASD of mean age 6.58 +/- 3.72 were included in the study. Based on clinical and v-EEG assessments, three groups of patients were defined: 1) patients with epilepsy (n = 17; 15.2%); 2) patients with epileptiform discharges in absence of clinical seizures (n = 14; 12.5%); 3) patients without epilepsy and without epileptiform discharges ( n = 81; 72.3%). There were no significant differences between three groups of patients on ADI-R subscores. Speech development was also not significantly related to epilepsy. There was a slight tendency of the VABS-II motor skills score to be higher in the group of patients with autism without clinical diagnosis of epilepsy and without subclinical epileptiform discharges (p  lt  0.05) in comparison with the two other groups. According to this tendency, we might claim that patients with higher scores on motor skills could have 0.88 times lower odds for having epileptiform EEG activity. Conclusions: According to our results, we were not able to detect differences in the ADI-R between the three populations with ASD, all with unknown etiology. Epilepsy, as well as subdinical epileptic discharges, showed small effects on Motor Skills in patients with autism, and had no effect on adaptive behavior Communication/Socialization/Daily Living Skills.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Epilepsy & Behavior
T1  - Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders
EP  - 52
SP  - 45
VL  - 92
DO  - 10.1016/j.yebeh.2018.12.011
ER  - 

@article{
author = "Milovanović, Maja and Radivojević, Vlada and Radosavljev-Kirćanski, Jelena and Grujicić, Roberto and Tošković, Oliver and Aleksić-Hil, Olivera and Pejović-Milovančević, Milica",
year = "2019",
abstract = "Purpose: The purpose of this study was to determine the prevalence of epilepsy and subclinical epileptiform abnormalities in children with autism spectrum disorder (ASD), and to investigate its effects on core autistic symptoms and adaptive behavior skills. Methods: Patients with diagnosis of ASD who met full criteria on Autism Diagnostic Interview-Revised (ADI-R) were included in the study. Adaptive behavior skills were assessed by Vineland Adaptive Behavior Scale-II (VABS-II). Clinical assessment for epilepsy and video electroencephalography (EEG) (v-EEG) examinations during wakefulness and/or sleep were prospectively performed in all patients. Results: A total of 112 patients with diagnosis of ASD of mean age 6.58 +/- 3.72 were included in the study. Based on clinical and v-EEG assessments, three groups of patients were defined: 1) patients with epilepsy (n = 17; 15.2%); 2) patients with epileptiform discharges in absence of clinical seizures (n = 14; 12.5%); 3) patients without epilepsy and without epileptiform discharges ( n = 81; 72.3%). There were no significant differences between three groups of patients on ADI-R subscores. Speech development was also not significantly related to epilepsy. There was a slight tendency of the VABS-II motor skills score to be higher in the group of patients with autism without clinical diagnosis of epilepsy and without subclinical epileptiform discharges (p  lt  0.05) in comparison with the two other groups. According to this tendency, we might claim that patients with higher scores on motor skills could have 0.88 times lower odds for having epileptiform EEG activity. Conclusions: According to our results, we were not able to detect differences in the ADI-R between the three populations with ASD, all with unknown etiology. Epilepsy, as well as subdinical epileptic discharges, showed small effects on Motor Skills in patients with autism, and had no effect on adaptive behavior Communication/Socialization/Daily Living Skills.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Epilepsy & Behavior",
title = "Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders",
pages = "52-45",
volume = "92",
doi = "10.1016/j.yebeh.2018.12.011"
}

Milovanović, M., Radivojević, V., Radosavljev-Kirćanski, J., Grujicić, R., Tošković, O., Aleksić-Hil, O.,& Pejović-Milovančević, M.. (2019). Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders. in Epilepsy & Behavior
Academic Press Inc Elsevier Science, San Diego., 92, 45-52.
https://doi.org/10.1016/j.yebeh.2018.12.011

Milovanović M, Radivojević V, Radosavljev-Kirćanski J, Grujicić R, Tošković O, Aleksić-Hil O, Pejović-Milovančević M. Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders. in Epilepsy & Behavior. 2019;92:45-52.
doi:10.1016/j.yebeh.2018.12.011 .

Milovanović, Maja, Radivojević, Vlada, Radosavljev-Kirćanski, Jelena, Grujicić, Roberto, Tošković, Oliver, Aleksić-Hil, Olivera, Pejović-Milovančević, Milica, "Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders" in Epilepsy & Behavior, 92 (2019):45-52,
https://doi.org/10.1016/j.yebeh.2018.12.011 . .

TY  - JOUR
AU  - Carakovac, Mia
AU  - Jovanović, Jelena
AU  - Kalanj, Marko
AU  - Rudić, Nenad
AU  - Aleksić-Hil, Olivera
AU  - Aleksić, Branko
AU  - Villalobos, Itzel Bustos
AU  - Kasuya, Hideki
AU  - Ozaki, Norio
AU  - Lečić-Toševski, Dušica
AU  - Pejović-Milovančević, Milica
PY  - 2016
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/988
AB  - Early detection of Autism Spectrum Disorder (ASD) has proven to be of high significance, however there is a limited availability of ASD screening tools in Serbian language. In this study we aim to translate, assess reliability and, in part, test the applicability of Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT R/F) in Serbian Healthcare environment. We screened 128 children in three primary healthcare centres and 20 children in a tertiary psychiatric center, using M-CHAT R/F translated into Serbian language, between December 2014 and October 2015. At the end of the screening process 80% of participants in the risk group screened positive for ASD, while in the control group 4 (3.1%) participants screened positive, with a mean total scores of 8.25 and 0.66 respectively. The Cronbach's a coefficient was 0.91 and Guttman's.6 was 0.93. Test-retest reliability was deemed as acceptable, and no significant correlation was found between M-CHAT-R/F scores and Epworth Sleepiness Scale for children scores. The Serbian version of the M-CHAT-R/F has shown satisfactory reliability. We can therefore assert that it is a reliable tool for identifying ASD and it can be used in clinical practice to improve early detection, assessment and treatment.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Serbian Language version of the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up: Cross-Cultural Adaptation and Assessment of Reliability
VL  - 6
DO  - 10.1038/srep38222
ER  - 

@article{
author = "Carakovac, Mia and Jovanović, Jelena and Kalanj, Marko and Rudić, Nenad and Aleksić-Hil, Olivera and Aleksić, Branko and Villalobos, Itzel Bustos and Kasuya, Hideki and Ozaki, Norio and Lečić-Toševski, Dušica and Pejović-Milovančević, Milica",
year = "2016",
abstract = "Early detection of Autism Spectrum Disorder (ASD) has proven to be of high significance, however there is a limited availability of ASD screening tools in Serbian language. In this study we aim to translate, assess reliability and, in part, test the applicability of Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT R/F) in Serbian Healthcare environment. We screened 128 children in three primary healthcare centres and 20 children in a tertiary psychiatric center, using M-CHAT R/F translated into Serbian language, between December 2014 and October 2015. At the end of the screening process 80% of participants in the risk group screened positive for ASD, while in the control group 4 (3.1%) participants screened positive, with a mean total scores of 8.25 and 0.66 respectively. The Cronbach's a coefficient was 0.91 and Guttman's.6 was 0.93. Test-retest reliability was deemed as acceptable, and no significant correlation was found between M-CHAT-R/F scores and Epworth Sleepiness Scale for children scores. The Serbian version of the M-CHAT-R/F has shown satisfactory reliability. We can therefore assert that it is a reliable tool for identifying ASD and it can be used in clinical practice to improve early detection, assessment and treatment.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Serbian Language version of the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up: Cross-Cultural Adaptation and Assessment of Reliability",
volume = "6",
doi = "10.1038/srep38222"
}

Carakovac, M., Jovanović, J., Kalanj, M., Rudić, N., Aleksić-Hil, O., Aleksić, B., Villalobos, I. B., Kasuya, H., Ozaki, N., Lečić-Toševski, D.,& Pejović-Milovančević, M.. (2016). Serbian Language version of the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up: Cross-Cultural Adaptation and Assessment of Reliability. in Scientific Reports
Nature Publishing Group, London., 6.
https://doi.org/10.1038/srep38222

Carakovac M, Jovanović J, Kalanj M, Rudić N, Aleksić-Hil O, Aleksić B, Villalobos IB, Kasuya H, Ozaki N, Lečić-Toševski D, Pejović-Milovančević M. Serbian Language version of the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up: Cross-Cultural Adaptation and Assessment of Reliability. in Scientific Reports. 2016;6.
doi:10.1038/srep38222 .

Carakovac, Mia, Jovanović, Jelena, Kalanj, Marko, Rudić, Nenad, Aleksić-Hil, Olivera, Aleksić, Branko, Villalobos, Itzel Bustos, Kasuya, Hideki, Ozaki, Norio, Lečić-Toševski, Dušica, Pejović-Milovančević, Milica, "Serbian Language version of the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up: Cross-Cultural Adaptation and Assessment of Reliability" in Scientific Reports, 6 (2016),
https://doi.org/10.1038/srep38222 . .