TY  - JOUR
AU  - Marinković, Dragan
AU  - Marinković, Tatjana
AU  - Kokai, Enikoe
AU  - Barth, T.
AU  - Moller, P.
AU  - Wirth, Thomas
PY  - 2004
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/33
AB  - The c-Myc transcription factor regulates a wide set of genes involved in processes such as proliferation, differentiation and apoptosis. Therefore, altered expression of Myc leads to deregulation of a large number of target genes and, as a consequence, to tumorigenesis. For understanding Myc-induced transformation, identification of these target genes is essential. In this study, we searched for Myc target genes involved in lymphomagenesis using different mouse T and B cell lymphoma cell lines transformed by a conditional Myc-allele. Target genes obtained by microarray experiments were further subjected to a kinetic analysis of mRNA expression upon Myc inactivation/reactivation, bioinformatic examination of Myc binding sites and chromatin immunoprecipitation. This approach allowed us to define targets whose activation is a direct consequence of Myc binding. Among the 38 novel Myc targets, we identified several genes implicated in the tumor development. These genes are not only relevant for mouse lymphomas because we observed their upregulation in human lymphomas as well. Our findings further the understanding of Myc-induced lymphomagenesis and help toward developing more efficient antitumor strategies.
PB  - Oxford Univ Press, Oxford
T2  - Nucleic Acids Research
T1  - Identification of novel Myc target genes with a potential role in lymphomagenesis
EP  - 5378
IS  - 18
SP  - 5368
VL  - 32
DO  - 10.1093/nar/gkh877
ER  - 

@article{
author = "Marinković, Dragan and Marinković, Tatjana and Kokai, Enikoe and Barth, T. and Moller, P. and Wirth, Thomas",
year = "2004",
abstract = "The c-Myc transcription factor regulates a wide set of genes involved in processes such as proliferation, differentiation and apoptosis. Therefore, altered expression of Myc leads to deregulation of a large number of target genes and, as a consequence, to tumorigenesis. For understanding Myc-induced transformation, identification of these target genes is essential. In this study, we searched for Myc target genes involved in lymphomagenesis using different mouse T and B cell lymphoma cell lines transformed by a conditional Myc-allele. Target genes obtained by microarray experiments were further subjected to a kinetic analysis of mRNA expression upon Myc inactivation/reactivation, bioinformatic examination of Myc binding sites and chromatin immunoprecipitation. This approach allowed us to define targets whose activation is a direct consequence of Myc binding. Among the 38 novel Myc targets, we identified several genes implicated in the tumor development. These genes are not only relevant for mouse lymphomas because we observed their upregulation in human lymphomas as well. Our findings further the understanding of Myc-induced lymphomagenesis and help toward developing more efficient antitumor strategies.",
publisher = "Oxford Univ Press, Oxford",
journal = "Nucleic Acids Research",
title = "Identification of novel Myc target genes with a potential role in lymphomagenesis",
pages = "5378-5368",
number = "18",
volume = "32",
doi = "10.1093/nar/gkh877"
}

Marinković, D., Marinković, T., Kokai, E., Barth, T., Moller, P.,& Wirth, T.. (2004). Identification of novel Myc target genes with a potential role in lymphomagenesis. in Nucleic Acids Research
Oxford Univ Press, Oxford., 32(18), 5368-5378.
https://doi.org/10.1093/nar/gkh877

Marinković D, Marinković T, Kokai E, Barth T, Moller P, Wirth T. Identification of novel Myc target genes with a potential role in lymphomagenesis. in Nucleic Acids Research. 2004;32(18):5368-5378.
doi:10.1093/nar/gkh877 .

Marinković, Dragan, Marinković, Tatjana, Kokai, Enikoe, Barth, T., Moller, P., Wirth, Thomas, "Identification of novel Myc target genes with a potential role in lymphomagenesis" in Nucleic Acids Research, 32, no. 18 (2004):5368-5378,
https://doi.org/10.1093/nar/gkh877 . .