TY  - JOUR
AU  - Markišić, Merdin Š.
AU  - Pavlović, Aleksandra M.
AU  - Pavlović, Dragan
PY  - 2017
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/1070
AB  - We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p  lt  0.05), B12 level (r = -0.410, p  lt  0.01), and vitamin D levels (r = -0.465, p  lt  0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.
PB  - Hindawi Ltd, London
T2  - Biomed Research International
T1  - The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke
VL  - 2017
DO  - 10.1155/2017/5489057
ER  - 

@article{
author = "Markišić, Merdin Š. and Pavlović, Aleksandra M. and Pavlović, Dragan",
year = "2017",
abstract = "We explored the relationship between acute ischaemic stroke (IS) early functional outcome and serum levels of homocysteine, vitamin B12, and D in a noninterventional prospective clinical study. We enrolled 50 patients with first-ever IS and performed laboratory tests and functional assessment at three time points: on admission and three and six months after stroke. Modified Rankin Scale (mRS), NIHSS scale, and Barthel index (BI) scores were assessed in all participants by trained examiner blinded to laboratory data. Patients did not receive treatment that might alter laboratory data. Admission NIHSS correlated with homocysteine levels (r = 0.304, p  lt  0.05), B12 level (r = -0.410, p  lt  0.01), and vitamin D levels (r = -0.465, p  lt  0.01). Functional outcome measures (BI and mRS) did not significantly correlate with homocysteine and vitamin D3 levels at 3 and 6 months. However, a positive correlation with vitamin B12 levels was detected for BI both at 3 and 6 months and mRS at 6 months. Higher serum vitamin B12 levels were associated with better functional outcome at follow-up.",
publisher = "Hindawi Ltd, London",
journal = "Biomed Research International",
title = "The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke",
volume = "2017",
doi = "10.1155/2017/5489057"
}

Markišić, M. Š., Pavlović, A. M.,& Pavlović, D.. (2017). The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. in Biomed Research International
Hindawi Ltd, London., 2017.
https://doi.org/10.1155/2017/5489057

Markišić MŠ, Pavlović AM, Pavlović D. The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke. in Biomed Research International. 2017;2017.
doi:10.1155/2017/5489057 .

Markišić, Merdin Š., Pavlović, Aleksandra M., Pavlović, Dragan, "The Impact of Homocysteine, Vitamin B12, and Vitamin D Levels on Functional Outcome after First-Ever Ischaemic Stroke" in Biomed Research International, 2017 (2017),
https://doi.org/10.1155/2017/5489057 . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Markišić, Merdin Š.
AU  - Pavlović, Aleksandra M.
PY  - 2015
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/912
AB  - Vitamins are necessary factors in human development and normal brain function. Vitamin C is a hydrosoluble compound that humans cannot produce; therefore, we are completely dependent on food intake for vitamin C. Ascorbic acid is an important antioxidative agent and is present in high concentrations in neurons and is also crucial for collagen synthesis throughout the body. Ascorbic acid has a role in modulating many essential neurotransmitters, enables neurogenesis in adult brain and protects cells against infection. While SVCT1 enables the absorption of vitamin C in the intestine, SVCT2 is primarily located in the brain. Ascorbate deficiency is classically expressed as scurvy, which is lethal if not treated. However, subclinical deficiencies are probably much more frequent. Potential fields of vitamin C therapy are in neurodegenerative, cerebrovascular and affective diseases, cancer, brain trauma and others. For example, there is some data on its positive effects in Alzheimer's disease. Various dosing regimes are used, but ascorbate is safe, even in high doses for protracted periods. Better designed studies are needed to elucidate all of the potential therapeutic roles of vitamin C.
AB  - Vitamin su neophodni faktori za razvoj i normalnu funkciju mozga kod ljudi. Vitamin C je hidrosolubilno jedinjenje koje ljudski organizam ne može da sintetiše tako da smo potpuno zavisni od unosa putem hrane. Askorbinska kiselina je važno antioksidativno sredstvo i prisutna je u neuronima u visokim koncentracijama. Takođe je od ključnog značaja za sintezu kolagena u celom organizmu. Askorbinska kiselina ima ulogu u modulaciji mnogih bitnih neurotransmitera, omogućava neurogenezu u mozgu odraslog i štiti ćelije od infekcije. Dok SVCT1 omogućava apsorpciju vitamina C u crevima, SVCT2 se nalazi uglavnom u mozgu. Nedostatak askorbata klasično se ispoljava kao skorbut koji je letalan ako se ne leči, ali je supklinička deficijencija verovatno mnogo češća. Potencijalni terapijski domeni vitamina C terapije su neurodegenerativne, cerebrovaskularne i afektivne bolesti, karcinomi, traume mozga i drugi. Postoje na primer podaci o pozitivnim efektima askorbinske kiseline u Alchajmerovoj bolesti. Koriste se razni režimi doziranja, ali je askorbat pokazao bezbednost čak i u visokim dozama tokom dugih perioda. Potrebne su bolje dizajnirane studije da se razjasne sve potencijalne terapijske uloge vitamina C.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Serbian Journal of Experimental and Clinical Research
T1  - Vitamin C in neuropsychiatry
T1  - Vitamin C u neuropsihijatriji
EP  - 161
IS  - 2
SP  - 157
VL  - 16
DO  - 10.1515/SJECR-2015-0021
ER  - 

@article{
author = "Pavlović, Dragan and Markišić, Merdin Š. and Pavlović, Aleksandra M.",
year = "2015",
abstract = "Vitamins are necessary factors in human development and normal brain function. Vitamin C is a hydrosoluble compound that humans cannot produce; therefore, we are completely dependent on food intake for vitamin C. Ascorbic acid is an important antioxidative agent and is present in high concentrations in neurons and is also crucial for collagen synthesis throughout the body. Ascorbic acid has a role in modulating many essential neurotransmitters, enables neurogenesis in adult brain and protects cells against infection. While SVCT1 enables the absorption of vitamin C in the intestine, SVCT2 is primarily located in the brain. Ascorbate deficiency is classically expressed as scurvy, which is lethal if not treated. However, subclinical deficiencies are probably much more frequent. Potential fields of vitamin C therapy are in neurodegenerative, cerebrovascular and affective diseases, cancer, brain trauma and others. For example, there is some data on its positive effects in Alzheimer's disease. Various dosing regimes are used, but ascorbate is safe, even in high doses for protracted periods. Better designed studies are needed to elucidate all of the potential therapeutic roles of vitamin C., Vitamin su neophodni faktori za razvoj i normalnu funkciju mozga kod ljudi. Vitamin C je hidrosolubilno jedinjenje koje ljudski organizam ne može da sintetiše tako da smo potpuno zavisni od unosa putem hrane. Askorbinska kiselina je važno antioksidativno sredstvo i prisutna je u neuronima u visokim koncentracijama. Takođe je od ključnog značaja za sintezu kolagena u celom organizmu. Askorbinska kiselina ima ulogu u modulaciji mnogih bitnih neurotransmitera, omogućava neurogenezu u mozgu odraslog i štiti ćelije od infekcije. Dok SVCT1 omogućava apsorpciju vitamina C u crevima, SVCT2 se nalazi uglavnom u mozgu. Nedostatak askorbata klasično se ispoljava kao skorbut koji je letalan ako se ne leči, ali je supklinička deficijencija verovatno mnogo češća. Potencijalni terapijski domeni vitamina C terapije su neurodegenerativne, cerebrovaskularne i afektivne bolesti, karcinomi, traume mozga i drugi. Postoje na primer podaci o pozitivnim efektima askorbinske kiseline u Alchajmerovoj bolesti. Koriste se razni režimi doziranja, ali je askorbat pokazao bezbednost čak i u visokim dozama tokom dugih perioda. Potrebne su bolje dizajnirane studije da se razjasne sve potencijalne terapijske uloge vitamina C.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "Vitamin C in neuropsychiatry, Vitamin C u neuropsihijatriji",
pages = "161-157",
number = "2",
volume = "16",
doi = "10.1515/SJECR-2015-0021"
}

Pavlović, D., Markišić, M. Š.,& Pavlović, A. M.. (2015). Vitamin C in neuropsychiatry. in Serbian Journal of Experimental and Clinical Research
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 16(2), 157-161.
https://doi.org/10.1515/SJECR-2015-0021

Pavlović D, Markišić MŠ, Pavlović AM. Vitamin C in neuropsychiatry. in Serbian Journal of Experimental and Clinical Research. 2015;16(2):157-161.
doi:10.1515/SJECR-2015-0021 .

Pavlović, Dragan, Markišić, Merdin Š., Pavlović, Aleksandra M., "Vitamin C in neuropsychiatry" in Serbian Journal of Experimental and Clinical Research, 16, no. 2 (2015):157-161,
https://doi.org/10.1515/SJECR-2015-0021 . .

TY  - JOUR
AU  - Pavlović, Dragan
AU  - Markišić, Merdin Š.
AU  - Pavlović, Aleksandra M.
AU  - Lačković, Maja
AU  - Božić, Marija M.
PY  - 2014
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/802
AB  - Vitamin A is essential for the early development and normal functioning of the brain throughout life. A deficiency of vitamin A is one of the leading causes of morbidity and mortality in developing countries, and subclinical deficiency is probably present worldwide. The main active molecule in vitamin A is retinoic acid, which is involved in vision, the immune system, skin health, olfaction and cognition (learning, memory, spatial functions, olfaction, etc.) through processes of neuroplasticity and neurogenesis. Vitamin A is involved in the regulation of about one-sixth of the human genome. It has non-genomic actions in protein translation and paracrine actions. Retinal vitamin A aldehyde is crucial for day and night vision. The best-known manifestation of hypovitaminosis A is night blindness but in more severe cases, it causes blindness. In the hypothalamus, vitamin A, with information from the retina, acts in circadian and seasonal regulation. Increased retinoic acid levels in the blood are associated with increased risk of depression, and lower levels have been connected with Alzheimer's disease, Parkinson's disease, cerebral ischemia, autistic spectrum disorders and schizophrenia. Higher doses and longer periods of treatment pose the threat of hypervitaminosis A. Vitamin A and its analogs are a promising new class of therapeutic agents in a wide spectrum of disorders, albeit with a narrow therapeutic window.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Vitamin a and the nervous system
EP  - 1590
IS  - 4
SP  - 1585
VL  - 66
DO  - 10.2298/ABS1404585P
ER  - 

@article{
author = "Pavlović, Dragan and Markišić, Merdin Š. and Pavlović, Aleksandra M. and Lačković, Maja and Božić, Marija M.",
year = "2014",
abstract = "Vitamin A is essential for the early development and normal functioning of the brain throughout life. A deficiency of vitamin A is one of the leading causes of morbidity and mortality in developing countries, and subclinical deficiency is probably present worldwide. The main active molecule in vitamin A is retinoic acid, which is involved in vision, the immune system, skin health, olfaction and cognition (learning, memory, spatial functions, olfaction, etc.) through processes of neuroplasticity and neurogenesis. Vitamin A is involved in the regulation of about one-sixth of the human genome. It has non-genomic actions in protein translation and paracrine actions. Retinal vitamin A aldehyde is crucial for day and night vision. The best-known manifestation of hypovitaminosis A is night blindness but in more severe cases, it causes blindness. In the hypothalamus, vitamin A, with information from the retina, acts in circadian and seasonal regulation. Increased retinoic acid levels in the blood are associated with increased risk of depression, and lower levels have been connected with Alzheimer's disease, Parkinson's disease, cerebral ischemia, autistic spectrum disorders and schizophrenia. Higher doses and longer periods of treatment pose the threat of hypervitaminosis A. Vitamin A and its analogs are a promising new class of therapeutic agents in a wide spectrum of disorders, albeit with a narrow therapeutic window.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Vitamin a and the nervous system",
pages = "1590-1585",
number = "4",
volume = "66",
doi = "10.2298/ABS1404585P"
}

Pavlović, D., Markišić, M. Š., Pavlović, A. M., Lačković, M.,& Božić, M. M.. (2014). Vitamin a and the nervous system. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 66(4), 1585-1590.
https://doi.org/10.2298/ABS1404585P

Pavlović D, Markišić MŠ, Pavlović AM, Lačković M, Božić MM. Vitamin a and the nervous system. in Archives of Biological Sciences. 2014;66(4):1585-1590.
doi:10.2298/ABS1404585P .

Pavlović, Dragan, Markišić, Merdin Š., Pavlović, Aleksandra M., Lačković, Maja, Božić, Marija M., "Vitamin a and the nervous system" in Archives of Biological Sciences, 66, no. 4 (2014):1585-1590,
https://doi.org/10.2298/ABS1404585P . .

TY  - JOUR
AU  - Markišić, Merdin Š.
AU  - Markišić, Mirsad Š.
AU  - Markišić, Sabina B.
AU  - Pavlović, Dragan
PY  - 2012
UR  - http://rfasper.fasper.bg.ac.rs/handle/123456789/585
AB  - We present a case of a young woman, age 34, who presented with recurrent Lyme neuroborreliosis (LNB). Her clinical profile consisted of a rare combination of two thirdstage manifestations, namely, progressive encephalomyelitis and peripheral neuritis, in both bouts of the disease. The epidemiological data were controversial, as she reported a tick bite only two months prior to the onset of symptoms. Negative magnetic resonance imaging (MRI) results excluded multiple sclerosis, vascular causes and tumours. Serological tests confirmed the Bb infection in the recommended twostep serological approach consisting of an enzyme-linked immunosorbent assay (ELISA) test for Borrelia burgdorferi (Bb) immunoglobulin G (IgG) and immunoglobulin M (IgM) and a Western blot (WB) as confirmatory analysis in the blood. Another controversial issue is the lack of pleocytosis. Atypical findings in our patient can be explained by a possible rare genotype of Bb. After treatment with oral doxycycline, she made an apparent remission, but after three months, she had another episode with signs of central and peripheral nervous system involvement, increased Bb antibodies and white matter changes on the MRI. This time, she was treated with intravenous ceftriaxone, 2 grams daily for four weeks. She showed no signs of LNB, both clinically and serologically, during a follow up lasting about a year. This case emphasises the importance of the clinical and serological findings and the use of ceftriaxone as the first line of treatment in LNB.
AB  - Mi predstavljamo slučaj mlade žene starosti 34 godine sa rekurentnom Lajmskom neuroboreliozom (LNB). Njena klinička slika se sastojala od retke kombinacije dve manifestacije treće faze, naime, progresivnog encefalomijelitisa i perifernog neuritisa u obe epizode bolesti. Epidemiološki podaci su kontroverzni jer se ubod krpelja desio samo dva meseca ranije. Magnetna rezonanca (MR) mozga je isključila multiplu sklerozu, vaskularne uzroke i tumor. Serološki testovi su potvrdili Bb infekcije u preporučenoj serologiji u dva koraka, sa enzyme-linked immunosorbent assay (ELISA) testom za Borrelia burgdorferi (Bb) specifične imunoglobuline G (IgG) i imunoglobulina M (IgM) i Vestern Blot (VB) testom za konfirmaciju. Drugo kontroverzno pitanje je nedostatak pleocitoze u likvoru. Atipični nalazi u naše bolesnice mogu se objasniti retkim genotipom Bb. Nakon tretmana sa oralnim doksiciklinom, bolesnica je postigla remisiju, ali je posle tri meseca imala još jednu epizodu sa znacima zahvaćenosti centralnog i perifernog nervnog sistema, povećanim titrom specifičnih Bb antitela kao i promenama bele mase na MR mozga. Ovaj put, ona je tretirana ceftriaksonom intravenski, dva grama dnevno tokom četiri nedelje. Bolesnica je ponovo ušla u remisiju LNB koja se održavala i klinički i serološki tokom praćenja u trajanju od oko godinu dana. Ovaj slučaj naglašava značaj kliničkih i seroloških nalaza u dijagnostici kao i opravdanost ceftriaksona, kao prve linije lečenja u LNB.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Serbian Journal of Experimental and Clinical Research
T1  - Recidivant neuroborreliosis: Case report
T1  - Recidivantna neuroborelioza - prikaz slučaja
EP  - 156
IS  - 4
SP  - 151
VL  - 13
DO  - 10.5937/sjecr13-3134
ER  - 

@article{
author = "Markišić, Merdin Š. and Markišić, Mirsad Š. and Markišić, Sabina B. and Pavlović, Dragan",
year = "2012",
abstract = "We present a case of a young woman, age 34, who presented with recurrent Lyme neuroborreliosis (LNB). Her clinical profile consisted of a rare combination of two thirdstage manifestations, namely, progressive encephalomyelitis and peripheral neuritis, in both bouts of the disease. The epidemiological data were controversial, as she reported a tick bite only two months prior to the onset of symptoms. Negative magnetic resonance imaging (MRI) results excluded multiple sclerosis, vascular causes and tumours. Serological tests confirmed the Bb infection in the recommended twostep serological approach consisting of an enzyme-linked immunosorbent assay (ELISA) test for Borrelia burgdorferi (Bb) immunoglobulin G (IgG) and immunoglobulin M (IgM) and a Western blot (WB) as confirmatory analysis in the blood. Another controversial issue is the lack of pleocytosis. Atypical findings in our patient can be explained by a possible rare genotype of Bb. After treatment with oral doxycycline, she made an apparent remission, but after three months, she had another episode with signs of central and peripheral nervous system involvement, increased Bb antibodies and white matter changes on the MRI. This time, she was treated with intravenous ceftriaxone, 2 grams daily for four weeks. She showed no signs of LNB, both clinically and serologically, during a follow up lasting about a year. This case emphasises the importance of the clinical and serological findings and the use of ceftriaxone as the first line of treatment in LNB., Mi predstavljamo slučaj mlade žene starosti 34 godine sa rekurentnom Lajmskom neuroboreliozom (LNB). Njena klinička slika se sastojala od retke kombinacije dve manifestacije treće faze, naime, progresivnog encefalomijelitisa i perifernog neuritisa u obe epizode bolesti. Epidemiološki podaci su kontroverzni jer se ubod krpelja desio samo dva meseca ranije. Magnetna rezonanca (MR) mozga je isključila multiplu sklerozu, vaskularne uzroke i tumor. Serološki testovi su potvrdili Bb infekcije u preporučenoj serologiji u dva koraka, sa enzyme-linked immunosorbent assay (ELISA) testom za Borrelia burgdorferi (Bb) specifične imunoglobuline G (IgG) i imunoglobulina M (IgM) i Vestern Blot (VB) testom za konfirmaciju. Drugo kontroverzno pitanje je nedostatak pleocitoze u likvoru. Atipični nalazi u naše bolesnice mogu se objasniti retkim genotipom Bb. Nakon tretmana sa oralnim doksiciklinom, bolesnica je postigla remisiju, ali je posle tri meseca imala još jednu epizodu sa znacima zahvaćenosti centralnog i perifernog nervnog sistema, povećanim titrom specifičnih Bb antitela kao i promenama bele mase na MR mozga. Ovaj put, ona je tretirana ceftriaksonom intravenski, dva grama dnevno tokom četiri nedelje. Bolesnica je ponovo ušla u remisiju LNB koja se održavala i klinički i serološki tokom praćenja u trajanju od oko godinu dana. Ovaj slučaj naglašava značaj kliničkih i seroloških nalaza u dijagnostici kao i opravdanost ceftriaksona, kao prve linije lečenja u LNB.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "Recidivant neuroborreliosis: Case report, Recidivantna neuroborelioza - prikaz slučaja",
pages = "156-151",
number = "4",
volume = "13",
doi = "10.5937/sjecr13-3134"
}

Markišić, M. Š., Markišić, M. Š., Markišić, S. B.,& Pavlović, D.. (2012). Recidivant neuroborreliosis: Case report. in Serbian Journal of Experimental and Clinical Research
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 13(4), 151-156.
https://doi.org/10.5937/sjecr13-3134

Markišić MŠ, Markišić MŠ, Markišić SB, Pavlović D. Recidivant neuroborreliosis: Case report. in Serbian Journal of Experimental and Clinical Research. 2012;13(4):151-156.
doi:10.5937/sjecr13-3134 .

Markišić, Merdin Š., Markišić, Mirsad Š., Markišić, Sabina B., Pavlović, Dragan, "Recidivant neuroborreliosis: Case report" in Serbian Journal of Experimental and Clinical Research, 13, no. 4 (2012):151-156,
https://doi.org/10.5937/sjecr13-3134 . .